高等学校化学学报 ›› 2018, Vol. 39 ›› Issue (4): 623-628.doi: 10.7503/cjcu20170457

• 研究论文: 无机化学 • 上一篇    下一篇

近红外Ag2S量子点的合成及在生物成像中的应用

张丹1, 于金海2(), 李冬泽3, 周淼3, 张颖3   

  1. 1. 吉林大学第二医院, 长春 130022
    2. 吉林大学第一医院, 长春 130012
    3. 吉林大学化学学院, 长春 130012
  • 收稿日期:2017-07-13 出版日期:2018-04-10 发布日期:2018-03-26
  • 作者简介:联系人简介: 于金海, 男, 博士, 副主任医师. 主要从事肠胃相关医学生物成像方面的研究. E-mail:jidayujinhai@126.com
  • 基金资助:
    吉林省科技发展计划(批准号: 20140204005GX)资助

Preparation of High Quality Ag2S Quantum Dots with Near-Infrared Emission and Their Applications in Bioimaging

ZHANG Dan1, YU Jinhai2,*(), LI Dongze3, ZHOU Miao3, ZHANG Ying3   

  1. 1. The Second Hospital of Jilin University, Changchun 130022, China
    2. The First Hospital of Jilin University, Changchun 130012, China
    3. College of Chemistry, Jilin University, Changchun 130012, China
  • Received:2017-07-13 Online:2018-04-10 Published:2018-03-26
  • Contact: YU Jinhai E-mail:jidayujinhai@126.com
  • Supported by:
    † Supported by the Jilin Provincial Science and Technology Development Plan, China(No.20140204005GX).

摘要:

通过引入巯醇活化单质硫, 制备了近红外发射的高质量硫化银半导体量子点(粒径<4 nm). 该制备方法降低了反应温度, 避免了有毒前体的引入, 缩短了反应时间, 制备出的粒子尺寸均一, 单分散性较好. 制备的量子点的光致发光光谱表现出了量子尺寸效应, 其发射峰位置在700~830 nm范围之间可调. 将具有近红外光致发光特性的Ag2S纳米晶应用于细胞成像, 实验结果表明, 制备的量子点在细胞成像中清晰可见且毒性较低, 表现出了较好的应用潜力.

关键词: 硫化银, 量子点, 光致发光, 细胞成像

Abstract:

A new method for preparing Ag2S quantum dots(QDs) with near-infrared emission was presented by introducing the active sulfur precursor with alkylthiols as ligands. The high reactivity of sulfur precursor enables low temperature(< 120 ℃) syntheses, and produces Ag2S QDs with small size. As-prepared samples were well characterized by means of UV-Vis-NIR absorption spectroscopy, transmission electron microscopy(TEM), X-ray powder diffraction(XRD) and energy-dispersive X-ray spectroscopy(EDX). As a result, the size of as-prepared Ag2S QDs is tunable in a range from 1.7 nm to 3.5 nm with the inerease of reaction temperature from 50 ℃ to 120 ℃. Accordingly, the emission peak position of the Ag2S QDs can be tuned from 700 nm to 830 nm. Also, the biomedical imaging results indicate that the as-prepared Ag2S QDs is a nice carrier with low toxicity.

Key words: Ag2S, Quantum dots, Photoluminescence, Biomedical imaging

中图分类号: