高等学校化学学报 ›› 2015, Vol. 36 ›› Issue (11): 2134.doi: 10.7503/cjcu20150744

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SERS生物传感技术及其应用进展

付翠翠, 梁丽佳, 齐国华, 徐抒平, 徐蔚青()   

  1. 吉林大学理论化学研究所, 超分子结构与材料国家重点实验室, 长春 130012
  • 收稿日期:2015-09-22 出版日期:2015-11-10 发布日期:2015-10-23
  • 作者简介:联系人简介: 徐蔚青, 男, 博士, 教授, 博士生导师, 主要从事纳米结构与材料光谱学研究. E-mail:xuwq@jlu.edu.cn
  • 基金资助:
    国家自然科学基金(批准号: 20973075, 20903043, 91027010, 21373096)和科技部国家重大科学仪器设备开发专项项目(批准号: 2011YQ03012408)资助

Biomolecule-assisted Surface-enhanced Raman Scattering(SERS) Technology and SERS Biosensing

FU Cuicui, LIANG Lijia, QI Guohua, XU Shuping, XU Weiqing*()   

  1. State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry,Jilin University, Changchun 130012, China
  • Received:2015-09-22 Online:2015-11-10 Published:2015-10-23
  • Contact: XU Weiqing E-mail:xuwq@jlu.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(Nos.20973075, 20903043, 91027010, 21373096), the National Instrumentation Program(NIP) of the Ministry of Science and Technology of China(No.2011YQ03012408)

摘要:

表面增强拉曼散射(SERS)生物传感技术是以生物成分为敏感元件或探测对象, 研究生物分子间相互作用的重要工具之一, 被广泛应用于环境监测、 食品安全、 临床检验及疾病诊断等众多领域. 本文总结了耦合增强SERS生物传感技术方面的进展及其在分析检测和癌症诊断方面的应用. 主要包括基于耦合增强 SERS 生物传感技术方法、 高灵敏度的SERS传感芯片的制备及其应用和新型SERS技术研究癌细胞及组织.

关键词: 表面增强拉曼散射, 生物传感, SERS芯片, 免疫反应, 癌症

Abstract:

Biomolecule-assisted surface-enhanced Raman scattering(SERS) sensing is a technique using biological molecules as sensitive components or detected objects, which is one of the most important tools in the studies of biological molecules. SERS biosensing is widely used in environmental monitoring, food-safety, clinical testing, disease diagnosis, and many other areas. This paper summarizes the progresses on the application of SERS technique in the fields of the analysis and diagnosis of cancer. The contents mainly consist of three parts: (1) SERS biosensing technology based the new coupling mechanisms, involving SPR-coupling, waveguide-coupling and LSPR-PSPR coenhancement; (2) preparation and application of highly sensitive SERS chips; and (3) new SERS technology for investigating cancer cells and bio tissues.

Key words: Surface-enhanced Raman scattering, Biosensor, SERS chip, Immunoassay, Cancer

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