高等学校化学学报 ›› 2015, Vol. 36 ›› Issue (10): 2040.doi: 10.7503/cjcu20150520

• 高分子化学 • 上一篇    下一篇

氧化纤维素增强胶原水凝胶

张霞1, 周浩2(), 杨宇红3, 黄郁芳4, 陈新1()   

  1. 1. 聚合物分子工程国家重点实验室, 高分子及其先进复合材料协同创新中心,复旦大学高分子科学系, 先进材料实验室, 上海 200433
    2. 复旦大学附属眼耳鼻喉科医院, 上海 200031
    3. 复旦大学分析测试中心, 4. 材料科学系, 上海 200433
  • 收稿日期:2015-07-06 出版日期:2015-10-10 发布日期:2015-09-14
  • 作者简介:联系人简介: 陈 新, 男, 博士, 教授, 博士生导师, 主要从事生物大分子材料的研究. E-mail:chenx@fudan.edu.cn;周 浩, 男, 副教授, 副主任医师, 主要从事眼科临床及生物医用材料的研究. E-mail:zheent@139.com
  • 基金资助:
    国家自然科学基金(批准号: 21274028, 21374020)资助

Oxidized Cellulose Enhanced Collagen Hydrogels

ZHANG Xia1, ZHOU Hao2,*(), YANG Yuhong3, HUANG Yufang4, CHEN Xin1,*()   

  1. 1. State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China
    2. Eye Ear Nose & Throat Hospital, Fudan University, Shanghai 200031, China
    3. Research Centre for Analysis and Measurement,4. Department of Materials Science, Fudan University, Shanghai 200433, China
  • Received:2015-07-06 Online:2015-10-10 Published:2015-09-14
  • Contact: ZHOU Hao,CHEN Xin E-mail:zheent@139.com;chenx@fudan.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(Nos.21274028, 21374020)

摘要:

对纤维素进行氧化, 得到醛基化的氧化纤维素, 将其作为大分子交联剂制备了氧化纤维素改性胶原水凝胶. 通过扫描电镜、 力学性能及流变学测试, 对改性胶原水凝胶的结构和性能进行了表征. 研究结果表明, 与纯胶原水凝胶相比, 氧化纤维素改性胶原水凝胶的力学性能和热稳定性都得到了明显改善, 其压缩破坏强度比纯胶原水凝胶提高了1个数量级以上. 此外, 氧化纤维素的引入, 并未出现一般化学交联剂改性所带来的细胞毒性, 并保持了胶原水凝胶良好的生物相容性. 为改性胶原水凝胶在组织工程材料领域的应用提供依据.

关键词: 氧化纤维素, 蛋白质, 多糖, 组织工程, 胶原水凝胶, 力学性能

Abstract:

Aldehyde-functionalized cellulose(DAC) was obtained by the oxidization of cellulose, and was applied as a macromolecular crosslinker to modify the collagen(Col) hydrogel. The structures and properties of oxidized cellulose modified collagen(Col/DAC) hydrogels were characterized with SEM observation, mechanical test and rheology analysis. The results show that the mechanical properties and thermal stability of Col/DAC hydrogels are significantly improved compared to the pristine Col hydrogel, especially the breaking compression strength of Col/DAC hydrogel can be more than one order of magnitude higher than the pristine Col hydrogel. In addition, it is shown that introducing of oxidized cellulose does not bring the cytotoxicity that is often seen from the conventional chemical crosslinking method, and maintains the good biocompatibility of the final product. Therefore, such a biocompatible and strong collagen hydrogel obtained from the oxidized cellulose modification may have the great potential in tissue engineering and other biomedical fields.

Key words: Oxidized cellulose, Protein, Polysaccharide, Tissue engineering, Collagen hydrogel, Mechanical property

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