高等学校化学学报

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (3): 596.doi: 10.7503/cjcu20120877

• 物理化学 • 上一篇    下一篇

聚乙二醇和叶酸对层状双金属氢氧化物颗粒的表面修饰

夏志勇1, 杜娜1, 刘建强2, 侯万国1   

  1. 1. 山东大学胶体与界面化学教育部重点实验室, 济南250100;
    2. 山东大学物理学院, 济南250100
  • 收稿日期:2012-09-24 出版日期:2013-03-10 发布日期:2013-02-18
  • 通讯作者: 侯万国,男,博士,教授,主要从事胶体化学和油田化学方面的研究.E-mail:wghou@sdu.edu.cn E-mail:wghou@sdu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:21173135,50972082)和高等学校博士学科点专项科研基金(批准号:20110131130008)资助.

Surface Modification of Layer Double Hydroxide Particles by Poly(ethylene glycol) and Folic Acid

XIA Zhi-Yong1, DU Na1, LIU Jian-Qiang2, HOU Wan-Guo1   

  1. 1. Key Laboratory for Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, China;
    2. School of Physics, Shandong University, Jinan 250100, China
  • Received:2012-09-24 Online:2013-03-10 Published:2013-02-18

PDF (PC)

被引次数

11

摘要：

以具有伪装隐形作用的聚乙二醇(PEG)和具有靶向作用的叶酸(FA)为修饰剂, 以氨丙基三甲氧基硅烷(APTMS)为连接剂, 对Mg3Al-NO3层状双金属氢氧化物(LDH)进行了表面修饰, 制备了LDH-PEG-FA纳米颗粒, 并通过X射线衍射(XRD)、 透射电子显微镜(TEM)、 紫外-可见光谱(UV-Vis)、 傅里叶变换红外光谱(FTIR)、 粒度分布分析和元素分析等技术对其结构进行了表征. 结果表明, PEG和FA的修饰量可由其原料配比调控, 修饰后的产物具有良好的水再分散性, 这主要源于修饰层的空间位阻效应. 预期LDH-PEG-FA同时具有伪装隐形性和靶向性, 可用于药物载体等领域.

关键词: 层状双金属氢氧化物, 聚乙二醇, 叶酸, 表面修饰, 再分散性

Abstract:

Using (3-aminopropyl)trimethoxy silane(APTMS) as linker agent, the Mg3Al-NO3 layer double hydroxides(LDH) particles surface were modified by poly(ethylene glycol)(PEG) with disguise function and folic acid(FA) with targeted function. The obtained surface modified LDH particles(LDH-PEG-FA) were characterized by X-ray diffraction(XRD), transmission electron microscope(TEM), UV-Vis spectrometer, Fourier transform infrared spectrometer(FTIR), laser particle size analyzer and elemental analysis(EA), respectively. The results show that the surface modification of LDH particles can be controlled by the variation of the amount of PEG and FA used in raw materials. Particularly, the modified products exhibit good water re-dispersibility which is mainly attributed to the space steric effect of the modified layers. As the characteristic of disguising and targeting, the LDH-PEG-FA is expected to be used in drug delivery field.

Key words: Layer double hydroxide(LDH), Poly(ethylene glycol), Folic acid(FA), Surface modification, Re-dispersibility

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