高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (09): 1920.doi: 10.3969/j.issn.0251-0790.2012.09.008

• 研究论文: 无机化学 • 上一篇    下一篇

光诱导富精氨酸多肽修饰的Fe2O3@Au纳米粒子的细胞毒性

刘桂锋1, 高忠礼1, 余琼1, 张惠茅1, 王振新2   

  1. 1. 吉林大学中日联谊医院, 长春 130033;
    2. 中国科学院长春应用化学研究所, 电分析国家重点实验室, 长春 130022
  • 收稿日期:2011-11-18 出版日期:2012-09-10 发布日期:2012-08-14
  • 通讯作者: 张惠茅,女,博士,教授,主要从事放射影像学研究.E-mail:huimaozhanglinda@163.com E-mail:huimaozhanglinda@163.com
  • 基金资助:

    科技部纳米重大研究计划(批准号: 2011CB935800)资助.

Light Induced Cellular Cytotoxicity of Rich Arginine Peptide Modified Ferric Oxide Core Gold Shell Nanoparticles

LIU Gui-Feng1, GAO Zhong-Li1, YU Qiong1, ZHANG Hui-Mao1, WANG Zhen-Xin2   

  1. 1. China-Japan Union Hospital, Jilin University, Changchun 130033, China;
    2. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2011-11-18 Online:2012-09-10 Published:2012-08-14
  • Contact: ZHANG HuiMao E-mail:huimaozhanglinda@163.com

摘要:

以人宫颈癌细胞(HeLa细胞)为对象考察了富精氨酸多肽RRRRRRRR(R8)修饰的金-三氧化二铁壳核纳米粒子(R8-Fe2O3@Au NPs)对活细胞的光毒性. 研究结果表明, 内化后的R8-Fe2O3@Au NPs对活HeLa细胞无显著的细胞毒性, 但在激光照射下则可导致HeLa细胞的凋亡, 表现出很强的细胞光毒性. R8-Fe2O3@Au NPs的细胞光毒性与照射激光波长有关, 并随细胞吞噬的R8-Fe2O3@Au NPs的量、 光照强度和时间的增加而增强.

关键词: 金-三氧化二铁壳核纳米粒子, 多肽, 光毒性, 活细胞

Abstract:

The laser induced cellular cytotoxicity of rich arginine peptide RRRRRRRR(R8) modified ferric oxide core gold shell nanoparticles(R8-Fe2O3@Au NP) was studied. Although R8-Fe2O3@Au NP has a low cytotoxicity, the viability of nanoparticles internalized HeLa cell can be decreased by laser irradiation. The experimental result indicates that the R8-Fe2O3@Au NPs have significant cellular phototoxicity under laser irradiation. In addition, the cellular phototoxicity of R8-Fe2O3@Au NPs is dependent on the wavelength of irradiation laser, and increased by the irradiating time and light intensity.

Key words: Fe2O3@Au nanoparticles, Peptide, Phototoxicity, Living cell

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