高等学校化学学报

高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (02): 426.doi: 10.3969/j.issn.0251-0790.2012.02.038

• 高分子化学 • 上一篇    下一篇

一种新型磁共振成像造影剂的制备及性能

杨晓露1, 杨兴旺1, 黄燕1, 张岐1,2, 吴静波1, 曹本男2, 张小燕1   

  1. 1. 江苏大学化学化工学院, 镇江 212013;
    2. 海南大学海南精细化工重点实验室, 海口 570228
  • 收稿日期:2011-03-01 出版日期:2012-02-10 发布日期:2012-01-13
  • 通讯作者: 张 岐, 男, 教授, 博士生导师, 主要从事天然高分子及医学影像研究. E-mail: qzhang@ujs.edu.cn E-mail:qzhang@ujs.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 20871061)、江苏省科技支撑计划(批准号: SBE201077304)、海南大学奖励基金(批准号: hd09xm07/24)、海南省自然科学基金(批准号: 209001)和江苏大学学生科研立项(批准号: 09A053)资助.

Synthesis and Properties of a Novel Contrast Agent

YANG Xiao-Lu1, YANG Xing-Wang1, HUANG Yan1, ZHANG Qi1,2, WU Jing-Bo1, CAO Ben-Nan2, ZHANG Xiao-Yan1   

  1. 1. School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China;
    2. Hainan University, Hainan Provincial Key Lab of Fine Chemicals, Haikou 570228, China
  • Received:2011-03-01 Online:2012-02-10 Published:2012-01-13

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被引次数

15

摘要： 通过酰化反应将窄分子量分布的低聚壳聚糖(CSn, n＝6, 8, 11)引入到二乙三胺五乙酸(DTPA)中得到新型配体, 再与Mn2+配位得到3种顺磁性Mn(Ⅱ)基配合物, 其结构用IR、元素分析及电感耦合等离子体发射仪(ICP-AES)进行表征. 测定了配合物的纵向弛豫率(r1), 结果表明, 这类造影剂的弛豫率高于商业化医用的磁共振成像对比剂Gd-DTPA. 通过等温滴定微量热法(ITC)测定了功能配合物与牛血清白蛋白(BSA)相互作用的热力学参数.

关键词: 造影剂, 壳聚糖, 弛豫率, 等温滴定微量热(ITC)

Abstract: Chitosan oligosaccharides(CSn, n=6, 8, 11) with narrow molecular weight distribution and low polymerization degree were introduced into diethylenetriamine pentaacetic(DTPA) by acylation reaction. The synthesized novel ligands were coordinated to Mn2+, then the paramagnetic Mn2+-based complexes were gained. The structures of synthesized ligands and the corresponding complexes were characterized by IR, elemental analysis, and ICP-AES. The longitudinal relaxivities(r1) were measured. The results show that r1 of Mn-DTPA-CSn are higher than that of commercial contrast agent Gd-DTPA. Besides, the thermodynamical parameters of the interaction between the functional complexes and bovine serum albumin(BSA) were conducted by isothermal titration calorimetry(ITC).

Key words: Contrast agent, Chitosan, Relaxivity, Isothemal titration calorimetry(ITC)

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