Synthesis and Antitumor Activity of Lanthanum(Ⅲ) Complexes to N-Alkyl-1,10-phenanthroline-2-methanamine

Chem. J. Chinese Universities

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Synthesis and Antitumor Activity of Lanthanum(Ⅲ) Complexes to N-Alkyl-1,10-phenanthroline-2-methanamine

LI Feng-Hua^1,2, WU Hong-Xing², LIN Hua-Kuan²

1. College of Chemistry and Molecule Engineering, Qindao University of Science and Technology, Qingdao 266042, China;
2. College of Chemistry, Nankai University, Tianjin 300071, China

Received:2006-03-17 Revised:1900-01-01 Online:2006-10-10 Published:2006-10-10
Contact: LI Feng-Hua

Abstract

Abstract: Five lathanum(Ⅲ) complexes containing 1,10-phenanthroline units were synthesized and characterized by elemental analyses, ¹H HMR and IR spectra. All complexes were assayed for antitumor activity in vitro against HL-60(human leukocytoma) cells, PC-3MIE8(human prostate carcinoma) cells, BGC-823(human stomach carcinoma) cells, MDA-MB-435(human galactophore carcinoma) cells, Bel-7402(human liver carcinoma) cells and Hela(human cervix carcinoma) cells. The results show that the complexes exhibit good growth inhibition against different cell lines in general. DNA binding studies indicate that the complexes possibly interact with ctDNA by part intercalative, covalent binding and electrostatic effection.

Key words: Phenanthroline, La(Ⅲ) complex, Antitumor activity, DNA

CLC Number:

O614

TrendMD:

LI Feng-Hua^1,2, WU Hong-Xing², LIN Hua-Kuan². Synthesis and Antitumor Activity of Lanthanum(Ⅲ) Complexes to N-Alkyl-1,10-phenanthroline-2-methanamine[J]. Chem. J. Chinese Universities, doi: .

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Synthesis and Antitumor Activity of Lanthanum(Ⅲ) Complexes to N-Alkyl-1,10-phenanthroline-2-methanamine

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