Preparation of a Novel Amphiphilic Copolymer Microspheres with Phenylborate Moieties and Its Glucose-sensitive Properties

Chem. J. Chinese Universities

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Preparation of a Novel Amphiphilic Copolymer Microspheres with Phenylborate Moieties and Its Glucose-sensitive Properties

TANG Yu, WANG Zhen, LI Chao-Xing*

Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

Received:2007-01-25 Revised:1900-01-01 Online:2007-08-10 Published:2007-08-10
Contact: LI Chao-Xing

Abstract

Abstract: A novel amphiphilic copolymer was prepared via copolymerization of N-acryloyl-3-aminophenylboronic acid with β-cyclodextrin containing maleic anhydride. The copolymer was characterized with ¹³C NMR, IR and UV-Vis techniques. The self-assembling morphology of the polymer microspheres in methanol was studied via SEM. The reaction mechanism of polymer with methanol and self-assembling mechanism were discussed with research on the solubility of the polymer in various solvents. Gliclazide as the model drug was loaded in the copolymer microspheres and the drug release oscillating behavior was studied. The results indicate that the microspheres respond to glucose rapidly in 30 min, and the microspheres exhibit self-regulated“on-off” release behavior between the solution with 3 g/L of the glucose and the medium without glucose.

Key words: N-acryloyl-3-aminophenylboronic acid, β-cyclodextrin, Drug release, Self assembling microsphere, Glucose sensitive property

CLC Number:

O634.3+1

TrendMD:

TANG Yu, WANG Zhen, LI Chao-Xing*. Preparation of a Novel Amphiphilic Copolymer Microspheres with Phenylborate Moieties and Its Glucose-sensitive Properties[J]. Chem. J. Chinese Universities, doi: .

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Preparation of a Novel Amphiphilic Copolymer Microspheres with Phenylborate Moieties and Its Glucose-sensitive Properties

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