Effect of Mesoporous Silica Pore Structure on the Release Profiles of Captopril Drug

Chem. J. Chinese Universities

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Effect of Mesoporous Silica Pore Structure on the Release Profiles of Captopril Drug

QU Feng-Yu¹*, CUI Ling-Fei¹, HUANG Shi-Ying², ZHU Guang-Shan²*

1. Department of Chemistry, Harbin Normal University, Harbin 150080, China;
2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China

Received:2006-10-20 Revised:1900-01-01 Online:2007-08-10 Published:2007-08-10
Contact: ZHU Guang-Shan

Abstract

Abstract: A series of mesoporous silica with variable pore structures were prepared. The influence of mesoporous structure on drug release profiles was studied. It is found that mesoporous pore structure has a great effect on the drug release rate. The cubic pore structure MCM-48 has a faster drug release rate than that of MCM-41 system; while SBA-16 with “cage-like” pore structure system has the lowest drug release rate.

Key words: Mesoporous silica, Pore structure, Captopril, Release property

CLC Number:

O614

TrendMD:

QU Feng-Yu¹*, CUI Ling-Fei¹, HUANG Shi-Ying², ZHU Guang-Shan²*. Effect of Mesoporous Silica Pore Structure on the Release Profiles of Captopril Drug[J]. Chem. J. Chinese Universities, doi: .

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Effect of Mesoporous Silica Pore Structure on the Release Profiles of Captopril Drug

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