Syntheses of Novel Organogermanium Compounds Containing α-Amino Acid and Studies on the Antitumor Activity

Chem. J. Chinese Universities

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Syntheses of Novel Organogermanium Compounds Containing α-Amino Acid and Studies on the Antitumor Activity

CHEN Jian-Xin¹, CHEN Li¹, ZHAI Yu-Ping², SHI Yin², SUN Li-Juan¹

1. State Key Laboratory of Elemento-Organic Chemistry,
2. Department of Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

Received:2005-06-27 Revised:1900-01-01 Online:2006-08-10 Published:2006-08-10
Contact: SUN Li-Juan

Abstract

Abstract: In order to search new organogermanium antitumor drugs with an activity and low toxicity, 20 new organogermanium compounds were designed and synthesized by attaching α-amino acid to organogermanium moieties. Their structures were confirmed by IR, ¹H NMR and elemental analysis. The crystal structure of Ph₃GeCH(Ph)CH₂CONHCH(CH₂COOC₂H₅)COOC₂H₅ were determined by X-ray diffraction. Three human neoplastic cell lines(KB, HCT-8 and Bel-7402) were used to screen these compounds. The results indicate that some compounds at 5 μmol/L show a weak in vitro antitumor activity.

Key words: Organogermanium compound, α-Amino acid, Crystal structure, Antitumor activity

CLC Number:

O621.3

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CHEN Jian-Xin¹, CHEN Li¹, ZHAI Yu-Ping², SHI Yin², SUN Li-Juan¹. Syntheses of Novel Organogermanium Compounds Containing α-Amino Acid and Studies on the Antitumor Activity[J]. Chem. J. Chinese Universities, doi: .

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Syntheses of Novel Organogermanium Compounds Containing α-Amino Acid and Studies on the Antitumor Activity

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