Novel Biomimetic Polymeric Micelles for Drug Delivery

Chem. J. Chinese Universities

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Novel Biomimetic Polymeric Micelles for Drug Delivery

XU Jian-Ping, CHEN Wei-Dong, JI Jian, SHEN Jia-Cong

Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

Received:2006-08-10 Revised:1900-01-01 Online:2007-02-10 Published:2007-02-10
Contact: JI Jian

Abstract

Abstract: Novel amphiphilic polymers, cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems. Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture. Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method. The release of ADR from the nanosphere continued over 7 d. The drug-loaded micelles could effectively restrain the growth of cancer cell. These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.

Key words: Polymeric micelles, Biomimetic of cell membrane, Drug sustained release, Biocompatibility, Phosphorylcholine

CLC Number:

O631.3

TrendMD:

XU Jian-Ping, CHEN Wei-Dong, JI Jian, SHEN Jia-Cong. Novel Biomimetic Polymeric Micelles for Drug Delivery[J]. Chem. J. Chinese Universities, doi: .

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Novel Biomimetic Polymeric Micelles for Drug Delivery

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