Loaded and in vitro Drug Release of Anticancer Drugs in Porous Metal-Organic Frameworks

doi:10.3969/j.issn.0251-0790.2012.01.004

Abstract

Abstract: Porous metal-organic frameworks(MOF-5) were synthesized and the structure of synthetic MOF-5 was confirmed by XRD and IR spectrum. According to the result of TG, the synthetic MOF-5 displayed better thermo-stabilization. The capsaicin or 5-fluouourail was loaded in synthetic MOF-5 and in vitro drug release profile were investigated, respectively. The highest drug loading rates are 0.592 g/g MOF for capsaicin and 0.315 g/g MOF for 5-FU in drug-loaded MOF-5, respectively. The in vitro drug release profile of both MOF-5 formulations showed a clear biphasic release pattern. Cytotoxicity test showed that MOF-5 displayed good biocompatility.

Key words: Metal-organic framework(MOF), Capsaicin, 5-Fluouourail(5-FU), Drug loading rate, Drug sustained release, Cytotoxicity

CLC Number:

O614
O636.9

TrendMD:

YANG Bao-Chun, JIANG Yao-Dong, QIN Xue-Juan, CHEN Zhi-Liang, REN Fei. Loaded and in vitro Drug Release of Anticancer Drugs in Porous Metal-Organic Frameworks[J]. Chem. J. Chinese Universities, 2012, 33(01): 26.

References

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