Enzymatic Biodegradation and Thermal Properties of Phosphorylcholine Functionalized Poly(butylene succinate)

doi:10.3969/j.issn.0251-0790.2012.02.036

Abstract

Abstract: Enzymatic degradation of poly(butylene succinate)(PBS) and phosphorylcholine functionalized poly(butylene succinate)(PBS-PC) were performed in the presence of lipase AY30. It was found that PBS-PC was effectively biodegraded by lipase AY30, and PBS was hardly degraded even after an experimental time scale of 21 d. By means of differential scanning calorimetry(DSC), thermal properties of PBS and PBS-PC were studied. The results show that the melting point(T_m) of PBS-PC is decreased and glass transition tempe-rature(T_g) is increased compared with unmodified PBS. PBS-PC may have potential applications in biological environments as new carriers for controlled drug release, gene therapy, and scaffold for tissue engineering systems.

Key words: Lipase AY30, Enzymatic degradation, Poly(butylene succinate), Phosphorylcholine, Thermal stability

CLC Number:

O631

TrendMD:

ZHANG Shi-Ping, WANG Dan, DANG Yuan, SHI Su-Qing, GONG Yong-Kuan. Enzymatic Biodegradation and Thermal Properties of Phosphorylcholine Functionalized Poly(butylene succinate)[J]. Chem. J. Chinese Universities, 2012, 33(02): 416.

References

[1] Hao Q. H., Yang J., Li Q. B., Li Y., Jia L., Fang Q., Cao A. M.. Biomacromolecules[J], 2005, 6: 3474-3480 [2] ZHANG Shi-Ping(张世平), ZHU Xia-Xia(朱霞霞), GONG Yong-Kuan(宫永宽). Acta Chim. Sinica(化学学报)[J], 2009, 67(16): 1903-1909 [3] LUO Fa-Liang(罗发亮), ZHANG Xiu-Qin(张秀芹), LI Rong-Bo(李荣波), GAN Zhi-Hua(甘志华), JI Jun-Hui(季君晖), WANG Du-Jin(王笃金). Chem. J. Chinese Universities(高等学校化学学报)[J], 2010, 31(6): 1274-1279 [4] Chen Y. J., Zhan J., Zhang P., Nie S. B., Lu H. D., Song L., Hu Y.. Ind. Eng. Chem. Res.[J], 2010, 49: 8200-8208 [5] Ishii M., Okazaki M., Shibasaki Y., Ueda M., Teranishi T.. Biomacromolecules[J], 2001, 2: 1267-1270 [6] Yang J., Hao Q. H., Liu X. Y., Ba C. Y., Cao A. M.. Biomacromolecules[J], 2004, 5: 209-218 [7] Nagasaki Y., Okada T., Scholz C.. Macromolecules[J], 1998, 31: 1473-1479 [8] Miyauchi M., Li Y. J., Shimizu H.. Environ. Sci. Technol.[J], 2008, 42: 4551-4554 [9] Gu S. Y., Zhang K., Ren J., Zhan H.. Carbohydr. Polym.[J], 2008, 74: 79-85 [10] Liu L. F., Yu J. Y., Cheng L. D., Yang X. J.. Polym. Degrad. Stab.[J], 2009, 94: 90-94 [11] GONG Yong-Kuan(宫永宽), Winnik F. M.. Acta Chim. Sinica(化学学报)[J], 2005, 63: 643-647 [12] Gong M., Yang S., Ma J. N., Zhang S. P., Francoise M. W., Gong Y. K.. Surf. Sci.[J], 2008, 255: 555-558 [13] Yang S., Zhang S. P., Winnik F. M., Mwale F., Gong Y. K.. Biomed. Mater. Res.[J], 2008, 84A: 837-841 [14] XU Li-Zhen(徐黎珍), GONG Bo-Lin(龚波林). Chem. J. Chinese Universities(高等学校化学学报)[J], 2008, 29(11): 2138-2141 [15] LUO Juan(罗娟), WANG Li-Jian(王立坚), LUO Xiang-Lin(罗祥林). Polym. Mater. Sci. Eng.(高分子材料科学与工程)[J], 2006, 22: 25-29 [16] Nederberg F., Bowden T.,Nilsson B., Hong J., Hilborn J.. J. Am. Chem. Soc.[J], 2004, 126: 15350-15351 [17] Nederberg F., Bowen T., Hilborn J.. Macromolecules[J], 2004, 37: 954-965 [18] Yang J., Tian W. S., Li Q. B., Li Y., Cao A. M.. Biomacromolecules[J], 2004, 5: 2258-2268 [19] YANG Jing(杨晶). Synthesis and Characterization of Novel Biodegradable Polymers(新型生物降解性高分子的设计、合成及物理性质表征)[D], Shanghai: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 2004 [20] Staubli A., Mathiowitz E., Langer R.. Macromolecules[J], 1991, 24: 2291-2298 [21] Montaudo G., Rizzarelli P.. Polym. Degrad. Stab.[J], 2000, 70: 305-314 [22] Cho K., Lee J., Kwon K. J.. Polym. Sci.[J], 2000, 79: 1025-1033 [23] ZHANG Hai-Yun(张海云), WANG Ni(王妮), YU Jian-Yong(俞建勇), CAO A-Min(曹阿民). China Synthetic Fiber Industry(合成纤维工业)[J], 2007, 30: 13-16 [24] Zhang S. P., Yang J., Liu X. Y., Chang J. H., Cao A. M.. Biomacromolecules[J], 2003, 4: 437-445