Chem. J. Chinese Universities ›› 2013, Vol. 34 ›› Issue (1): 205.doi: 10.7503/cjcu20120430

• Polymer Chemistry • Previous Articles     Next Articles

Surface Modification of Polystyrene via Covalently-attaching Phosphorylcholine Zwitterion and Its Blood Compatibility

JIN Can1, JIANG Yu-Liang1, QIAN Tao1, HAN Qiao-Rong1, WANG Bing-Xiang1, SHEN Jian1,2   

  1. 1. Jiangsu Province Key Laboratory of Biofunctional Materials, Jiangsu Province Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China;
    2. Jiangsu Province Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
  • Received:2012-04-29 Published:2012-12-31

Abstract:

To be more compatible with blood, polystyrene(PS) was covalently-attached with phosphorylcholine(1) via ether bond. After activated by chloromethylation reaction, the PS was constructed with compound 1 by the reaction between benzyl chloride and hydroxyl group. The existence of phosphorylcholine structure onto the surface of PS was revealed by attenuated total reflection Fourier transform infrared spectroscopy(ATR-FTIR) and 1H NMR. The contact angle measurement of grafted PS membrane indicated that the grafted films possessed relatively hydrophilic surface. The blood compatibilities of grafted PS were evaluated by platelet-rich plasma adhesion experiment. The novel segmented PS containing phosphorylcholine structure improved blood compatibility.

Key words: Polystyrene, Phosphorylcholine zwitterion, Surface modification, Platelet adhesion, Antithrombogenic biomaterial

CLC Number: 

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