Hypoxia activated chemotherapy drug AQ4N and carbon dots self-assembly for chemotherapy combined with sonodynamic therapy of tumors

doi:10.7503/cjcu20240489

Chem. J. Chinese Universities

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Hypoxia activated chemotherapy drug AQ4N and carbon dots self-assembly for chemotherapy combined with sonodynamic therapy of tumors

PANG E¹, TANG Yuanyu¹, ZHAO Shaojing¹, CHENG Qiang¹, WANG Chen¹, CHEN Jianmin², LAN Minhuan¹

1. Central South University
2. Putian University

Received:2024-10-31 Revised:2024-12-05 Online:2024-12-09 Published:2024-12-09
Contact: Min-Huan LAN E-mail:minhuanlan@csu.edu.cn
Supported by:
Supported by the National Key Research and Development Program of China (No. 2022YFA1207600), the National Natural Science Foundation of China (Nos. 62375289, 62175262), and the Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University (No. PALM 202201)

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Abstract

Abstract: A red fluorescent emitting carbon dots (CDs) with sonodynamic activity were synthesized, and the CDs@AQ4N nano-assemblies were prepared by assembling the hypoxia-activating drug AQ4N, with CDs via electrostatic interaction, hydrogen bonding, and π-π interactions. CDs@AQ4N could effectively generate singlet oxygen (1O2) for sonodynamic therapy (SDT) of cancer cells. Moreover, the depletion of intra-tumor oxygen during SDT further exacerbated the tumor hypoxia, which activated AQ4N and converted it into cytotoxic AQ4, enabling fluorescence-imaging-guided combination of SDT and chemotherapy for the treatment of mice tumors. The excellent biosafety of CDs@AQ4N was confirmed by mouse major organ sections, blood routine and blood biochemical analyses.

Key words: Carbon dots, Hypoxic activation, Sonodynamic therapy, Chemotherapy, Synergistic therapy

CLC Number:

O615.4+2

TrendMD:

PANG E, TANG Yuanyu, ZHAO Shaojing, CHENG Qiang, WANG Chen, CHEN Jianmin, LAN Minhuan. Hypoxia activated chemotherapy drug AQ4N and carbon dots self-assembly for chemotherapy combined with sonodynamic therapy of tumors[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20240489.

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Hypoxia activated chemotherapy drug AQ4N and carbon dots self-assembly for chemotherapy combined with sonodynamic therapy of tumors

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