Chem. J. Chinese Universities ›› 2021, Vol. 42 ›› Issue (11): 3295.doi: 10.7503/cjcu20210464

• Review • Previous Articles     Next Articles

Coordination Porous Polymers for Targeting Subcellular Organelles: Bio-imaging, Diagnosis and Therapy

KE Mengting, YUAN Jiangpei, ZHANG Heng, FANG Yu()   

  1. College of Chemistry and Chemical Engineering,Hunan University,Changsha 410000,China
  • Received:2021-07-01 Online:2021-11-10 Published:2021-08-20
  • Contact: FANG Yu E-mail:yu.fang@hnu.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(22071049)

Abstract:

Due to the changes in the external environment and living habits, the incidence and mortality rate of cancer are increasing day by day, so the problem of cancer prevention and treatment needs to be solved urgently. In recent years, a variety of targeted drugs for tumor cells in vivo have been reported based on the properties of porous nanomaterials. Metal-organic framework(MOF) and porous coordination cage(PCC) can be modified to some extent due to their diverse structures, high design ability, and certain modifiability. Therefore, it has received the favor of many researchers and obtained considerable development. Although metal- organic frameworks and porous coordination cages have been extensively studied in the fields of gas adsorption separation, chiral separation, catalysis, fluorescence and sensing, and electrical conductivity, their applications in biomedical applications have not been fully explored. In this paper, the research work of metal-organic framework and porous coordination cage in imaging and diagnosis and treatment of organisms is summarized, and some problems existing in the application of coordinated porous polymers in the biomedical field are pointed out.

Key words: Metal-organic framework, Porous coordination cage, Sub-organelle targeting, Biological imaging, Cancer therapy

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