Synthesis and Properties on Promoting DNA Condensation of Polybenzimidazole Mn(Ⅱ) Complexes

doi:10.3969/j.issn.0251-0790.2012.06.006

Abstract

Abstract: Complexes [Mn(DTPB)Ac]Ac·8H₂O(1) and [Mn₂(DTPB)(NO₃)₂(H₂O)₂][Mn₂(DTPB)·(NO₃)₂·(H₂O)·(CH₃OH)](NO₃)₄·5CH₃OH·H₂O(2) were synthesized via 1,1,4,7,7-pentakis(1H-benzimidazol-2-ylmethyl)-1,4,7-triazaheptane(DTPB) as the main ligand and characterized by X-ray diffraction. The interaction between complexes 1 or 2 and DNA, examined by UV-Vis absorption spectra and viscosity experiments, indicated that the two Mn(Ⅱ) complexes have strong affinity for DNA. The interaction mechanism of the complexes with DNA was discussed. These Mn(Ⅱ) complexes can promote DNA condensation under neutral conditions, as illustrated by gelose gel electrophoresis and right angle light scattering(RALS). The morphologies of the DNA condensates were observed by transmission electron microscopy(TEM).

Key words: 1,1,4,7,7-Pentakis(1H-benzimidazol-2-ylmethyl)-1,4,7-triazaheptane(DTPB), Mn(Ⅱ) complex, Crystal structure, DNA condensation

CLC Number:

O614.7

TrendMD:

HUANG Xue-Ying, MENG Xiang-Gao, ZHANG Yan, WANG Li, LIU Chang-Lin. Synthesis and Properties on Promoting DNA Condensation of Polybenzimidazole Mn(Ⅱ) Complexes[J]. Chem. J. Chinese Universities, 2012, 33(06): 1151.

References

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