Construction of Chemotherapy-Photothermal Therapy-Self-enhanced Starvation Therapy Nanoplatform and Its Application in Breast Cancer Treatment

doi:10.7503/cjcu20240467

Abstract

Abstract:

In recent years， with the continuous development of nanotechnology， multifunctional nanocomposites have been widely applied in the field of tumor therapy. Due to the heterogeneity， complexity， and diversity of tumors， single treatment approaches often fail to achieve ideal therapeutic outcomes. Therefore， combining multiple treatment methods to achieve synergistic tumor therapy has become a research hotspot. This paper designs a novel nanotherapy platform. A polydopamine（PDA） shell was coated on the surface of Pt@mesoporous Au nanomaterials（Pt@Au）， and doxorubicin（DOX） was loaded into the PDA shell. The surface of the PDA shell was modified with glucose oxidase（GOx） and NH₂-PEG_5K-cRGD. NH₂-PEG_5K-cRGD can specifically bind to the overexpressed αvβ₃ integrin in tumor cells， facilitating the accumulation of the nanotherapy platform in the tumor region. DOX can damage the DNA of tumor cells and is used for chemotherapy. The excellent photothermal properties of mesoporous Au and PDA can be used for photothermal therapy. GOx can react with glucose in tumor cells to produce gluconic acid and H₂O₂， achieving starvation therapy. Pt， as a common peroxidase mimic， can catalyze the decomposition of H₂O₂ in tumor cells to generate O₂， alleviating the hypoxic tumor microenvironment and promoting starvation therapy. Therefore， the Pt@Au@PDA-DOX-GOx-cRGD possesses the ability to perform chemotherapy-photothermal therapy-self-enhanced starvation therapy for combined tumor treatment.

Key words: Nanotherapy platform, Chemotherapy, Photothermal therapy, Starvation therapy, Breast cancer

CLC Number:

O625.31

TrendMD:

MA Shuang, LYU Mingyang, ZHANG Citong, LIU Yi. Construction of Chemotherapy-Photothermal Therapy-Self-enhanced Starvation Therapy Nanoplatform and Its Application in Breast Cancer Treatment[J]. Chem. J. Chinese Universities, 2025, 46(1): 20240467.

Figures/Tables 20

References 22

1	Radosław M.， ACS Appl. Mater. Interfaces， 2018， 10（9）， 7541—7561
2	Zhao W. G.， Hu J.， Gao W. P.， ACS Appl. Mater. Interfaces， 2017， 9（28）， 23528—23535
3	Ma H. S.， Yu Q. Q.， Qu Y.， Zhu Y. F.， Wu C. T.， Bioactive Mater.， 2021， 6， 4558—4567
4	Bao Y. H.， Chen J. F.， Qiu H. Q.， Zhang C.， Huang P. T.， Mao Z. W.， Tong W. J.， ACS Appl. Mater. Interfaces， 2021， 13（21）， 24532—24542
5	Wang H.， Li J.， Wang Y. Q.， Gong X.， Xu X. X.， Wang J. Y.， Li Y. P.， Sha X. Y.， Zhang Z. W.， J. Controlled Release， 2020， 319， 25—45
6	Li W. T.， Liu S. K.， Dong S. M.， Gai S. L.， Zhang F. M.， Dong Y. S.， Yang D.， He F.， Zhong L.， Yang P. P.， Chem. Engin. J.， 2021， 405， 127027
7	Kumari R.， Sunil D.， Ningthoujam R. S.， J. Controlled Release， 2020， 319， 135—156
8	Hu H. M.， Yan X. F.， Wang H.， Tannka J.， Wang M. Z.， You W.， Li Z. B.， J. Mater. Chem. B， 2019， 7， 1116—1123
9	Hu C. L.， Wang J. Z.， Liu S. N.， Cai L. H.， Zhou Y.， Liu X. J.， Wang M.， Liu Z. D.， Pang M. L.， ACS Appl. Mater. Interfaces， 2021， 13（4）， 4825—4834
10	Yang C. L.， Liu Y. Z.， Su S.， Gao N.， Jing J.， Zhang X. L.， J. Mater. Chem. B， 2020， 8， 9943—9950
11	Zhang Y.， Lin L.， Liu L.， Liu F.， Sheng S.， Tian H. Y.， Chen X. S.， Biomaterials， 2019， 216， 119255
12	Kou Y. K.， Dai Z. C.， Cui P.， Hu F. Z.， Tian L.， Zhang F. F.， Duan H. Q.， Xia Q. Y.， Liu Q. Y.， Zheng X. W.， J. Mater. Chem. B， 2021， 9， 8480—8490
13	Huo T. T.， Chen L. L.， Nie H. F.， Li W. H.， Lin C. T.， Akhtar M.， Huang R. Q.， ACS Appl. Mater. Interfaces， 2022， 14（3）， 3675—3684
14	Cheng K. W.， Ling C. X.， Gu D. H.， Gao Z. G.， Li Y. J.， An P. J.， Zhang Y.， You C. Q.， Zhang R.， Sun B. W.， New J. Chem.， 2020， 44， 1524—1536
15	Du X.， Zhang T.， Ma G.， Gu X.， Wang G， Li J.， Int. J. Nanomed.， 2019， 14， 2233—2251
16	Gao G.， Jiang Y. W.， Guo Y. X.， Jia R. H.， Cheng X. T.， Deng Y.， Yu X. W.， Zhu Y. X.， Guo H. Y.， Sun W.， Liu X. Y.， Zhao J.， Yang S. H.， Yu Z. W.， Raya F. M. S.， Liang G. L.， Wu F. G.， Adv. Funct. Mater.， 2020， 30， 1909391
17	Chen W. H.， Yu K. J.， Hou J. W.， Pang H. H.， Weng W. H.， Lin W. S.， Yang H. W.， ACS Appl. Bio Mater.， 2021， 4（10）， 7485—7496
18	Ren J. J.， Zhang L.， Zhang Y. J.， Zhang W.， Cao Y.， Xu Z. G.， Cui H. J.， Kang Y. J.， Xue P.， Biomaterials， 2020， 234， 119771
19	Zou Y.， Liu W. J.， Sun W.， Du J. J.， Fan J. L.， Peng X. J.， Adv. Funct. Mater.， 2022， 2111853
20	Yang J. Z.， Ding J. X.， Chinese J. Appl. Chem.， 2022， 39（5）， 855—856
21	Liu Y.， Zhuang Y. L.， Ding J. X.， J. Funct. Poly.， 2023， 36（1）， 1—5
22	Lv H.， Xu D.， Henzie J.， Feng J.， Lopes A.， Yamauchi Y.， Liu B.， Chem. Sci.， 2019， 10， 6423

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