Functional Polyphenol-Arginine Self-assembled Nanodrug for Radiosensitization in Breast Cancer

doi:10.7503/cjcu20240226

Abstract

Abstract:

Breast cancer is one of the most common malignant tumors in women， and radiotherapy effectively improves the prognosis of breast cancer patients. In order to enhance the efficacy of radiotherapy for breast cancer， this study prepared composite nanoparticles（E-DA NPs） based on the chemical reaction-driven self-assembly of epigallocatechin gallate（EGCG）， D-arginine（D-Arg）， and formaldehyde in an aqueous medium， and explored their radiosensitizing effects. These composite nanoparticles effectively increased the half-life and bioavailability of EGCG drug delivery， inhibited tumor cell proliferation， and enhanced the radiation-induced damage to tumor cells. Additionally， in the tumor microenvironment， the reaction of high concentrations of H₂O₂ with D-Arg released nitric oxide（NO）， which reduced DNA damage repair levels， affected cell proliferation， enhanced the radiosensitivity of tumor cells， and improved tumor control and cure rates. This work， through the construction of polyphenol-arginine self-assembling nanomedicines， provides a new direction for developing novel radiotherapy sensitizers responsive to the tumor microenvironment.

Key words: Breast cancer, Polyphenol, Arginine, Nitric oxide, Radiosensitization

CLC Number:

O625

TrendMD:

NING Jiayu, HAO Pengfei, WANG Feng, YE Jiaquan, CHONG Yu. Functional Polyphenol-Arginine Self-assembled Nanodrug for Radiosensitization in Breast Cancer[J]. Chem. J. Chinese Universities, 2025, 46(1): 20240226.

Figures/Tables 8

References 23

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