Synthesis of Degradable Poly(polyamidoamine-methacrylamide-g-anhydride) Photocrosslinked Gels and Their Controlled Drug Release Behavior

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (5): 1194.

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Synthesis of Degradable Poly(polyamidoamine-methacrylamide-g-anhydride) Photocrosslinked Gels and Their Controlled Drug Release Behavior

CHEN Yang-Juan, ZHONG Shi-An*, SHI Qiong

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

Received:2010-08-05 Revised:2010-09-27 Online:2011-05-10 Published:2011-04-11
Contact: ZHONG Shi-An E-mail:zhongshian@yahoo.com.cn
Supported by:
湖南省自然科学基金(批准号: 06JJ4117)资助.

Abstract

Abstract: Polyamidoamine(PAMAM) dendrimers were methacylated by Methacryloyl chloride and photopolymerized with Methacrylated Sebacic Anhydride(MSA) to obtain degradable gels.Structures of the polymers were characterized by FT-IR and1H NMR. In order to study the effects of polyamidoamine double bond (PAMAM-DB):MSA ratio on the polymer degradation behavior, local pH, water uptake, mass loss and surface morphology in the course of degradation were explored.It is found that the gels containing 50-60wt% anhydride were good surface erosion materials. Degradation time and pH of degradable medium range from 45 to 60 days, and from 6.5 to 8.06, respectively.Sample with 50wt% anhydride was choosed as the bead of ofloxacin based on the degradation experiment.The result shows the drug-released time and content of drug could be controlled by varing the mass fraction of MSA.

Key words: Polyamidoamine-methacrylamide, Anhydride, Photocrosslink, Surface erosion, Controlled drug release.

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CHEN Yang-Juan, ZHONG Shi-An*, SHI Qiong. Synthesis of Degradable Poly(polyamidoamine-methacrylamide-g-anhydride) Photocrosslinked Gels and Their Controlled Drug Release Behavior[J]. Chem. J. Chinese Universities, 2011, 32(5): 1194.

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Synthesis of Degradable Poly(polyamidoamine-methacrylamide-g-anhydride) Photocrosslinked Gels and Their Controlled Drug Release Behavior

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