Inhibitory Effects of Aqueous Nanoparticle Suspensions of [60]Fullerene Derivatives on Bacterial Growth

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (4): 885.

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Inhibitory Effects of Aqueous Nanoparticle Suspensions of [60]Fullerene Derivatives on Bacterial Growth

YAO Lu, SONG Gao-Guang, HUANG Cheng, YANG Xin-Lin*

School of Life Science and Technology, Beijing Institute and Technology, Beijing 100081, China

Received:2010-06-01 Revised:2010-07-26 Online:2011-04-10 Published:2011-03-09
Contact: YANG Xin-Lin E-mail:xlyang@bit.edu.cn
Supported by:
国家自然科学基金(批准号: 20672012)和北京市自然科学基金(批准号: 2082020)资助.

Abstract

Abstract: The biological activities of fullerene nanoparticles have received extensive attention. The antibacterial effects of two aqueous nanoparticle suspensions of [60]fullerene derivatives, a bis-methanophosphonate fullerene (BMPF) and fullerol were studied for the first time. The results showed that both nano-BMPF and nano-fullerol could dose-dependently inhibit the growth of the gram-positive bacteria S. aureus under dark condition. The 50% inhibition concentration of two nanoparticle suspensions were 9.1 μM and 4.2 μM, respectively. It was also revealed that the antibacterial activity of nano-fullerol probably did not correlate to reactive oxygen species, but superoxide anions (O2.-) might be involved in the antibacterial action of nano-BMP. In addition, both aqueous nanoparticle suspensions couldn’t inhibit the growth of the gram-negative bacteria E. coli under dark condition. These results implied that nanoparticles of both fullerene derivatives might be potentially used as antibiotics in biomedicine.

Key words: Fullerene derivatives, Aqueous nanoparticle suspension, Antibacteria

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YAO Lu, SONG Gao-Guang, HUANG Cheng, YANG Xin-Lin*. Inhibitory Effects of Aqueous Nanoparticle Suspensions of [60]Fullerene Derivatives on Bacterial Growth[J]. Chem. J. Chinese Universities, 2011, 32(4): 885.

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Inhibitory Effects of Aqueous Nanoparticle Suspensions of [60]Fullerene Derivatives on Bacterial Growth

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