Abstract: Abstract A novel amphiphile containing two functional groups of both quinolinium and boronic acid, N-(boronobenzyl)-8-hexadecyloxyquinolinium bromide (BHQB), has been synthesized. Scanning electron microscopy (SEM) indicated the formation of bilayer vesicles in the ethanol/water solution (?=0.6). Differential scanning calorimrtry (DSC) established the presence of crystal-to-liquid crystal transition at 52.4 oC. The vesicular fluorescence properties upon binding with carbohydrates have been studied in ethanol/water buffer at pH 7.4. Addition of saccharides to the vesicular solution, the fluorescent intensities of quinoliniun in BHQB vesicles centered at 425 nm increased gradually and 508 nm decreased dramatically with increasing concentration of saccharides. The change tendency of fluorescent intensities of the BHQB vesicles with concentration of saccharides followed in the order of glucose > fructose. The pH profiles of the fluorescence intensity were studied in the absence and in the presence of sugars. These results suggest that the BHQB vesicles may be developed as a continuous monitoring and implantable fluorescence vesicular sensor, which might be applied in the practical field.

Key words: Keywords Fluorescence vesicular sensor, Saccharide, Boronic acid, Amphiphiles