Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (2): 236.

• Articles • Previous Articles     Next Articles

Promotion on Nucleation and Aggregation of Calcium Oxalate Crystals by Injury of HKC Cell

YAO Xiu-Qiong, DENG Sui-Ping, OUYANG Jian-Ming*   

  1. Institute of Biomineralization and Lithiasis Research,  Department of Chemistry, Jinan University, Guangzhou 510632, China
  • Received:2010-05-10 Revised:2010-09-26 Online:2010-02-10 Published:2011-02-23
  • Contact: Jian-Ming Ouyang E-mail:toyjm@jnu.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 20971057)资助.

Abstract: Human renal tubular epithelial cells (HKC) were injured by H2O2. Cell damage caused the decreased viability of HKC, and the increased expression of osteopontin (OPN), thus, the nucleation and aggregation of calcium oxalate crystals were promoted, and the percentage of the induced calcium oxalate monohydrate (COM) crystals increased, but the effect on growth of calcium oxalate crystals was not significant. The results suggest that damage of renal tubular epithelial cells might increase the risk of kidney stone formation.

Key words: Calcium oxalate, cell regulation, osteopontin, biomineralization, HKC cell

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