Abstract: The oxidation of alkane, alkene and carbonyl catalyzed by metallo-deuteroporphyrin derivatives were reviewed. Because of their closer relationship to monooxygenase P-450, metallo-deuteroporphyrin derivatives have higher catalytic activities than other metallo\|porphyrin derivates. The Co(Ⅱ)-3,8-diethyl deuteroporphyrin dimethyl ester was prepared from hemin by a four-steps reaction including demetalation, esterification, hydrogenation and complex reactions. Without the additional of organic solven and any coreductant, Co(Ⅱ)-3,8-diethyl deuteroporphyrin dimethyl ester was used as catalyst for cyclohexane oxidation using air as oxidant. The catalytic mechanism of this reaction was preliminary studied by UV-Vis spectra. The results indicated that the Co(Ⅱ)-3,8-diethyl deuteroporphyrin dimethyl ester which overcame the shortage of instabili\| ties of 3,8-divinyl of cobalt(Ⅱ) protoporphyrin IX dimethyl ester had satisfying catalytic activity in the oxidation of cyclohexane and the total yield of cyclohexanol and cyclohexanone was 16.9%.

Key words: Hemin, Porphyrin derivative, Catalytic oxidation, Mechanism