Metabolic Profiles of Nonylphenol in Rat Urine

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (10): 2280.

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Metabolic Profiles of Nonylphenol in Rat Urine

WANG Wei-Hua¹, LIU Chun-Hong¹, SUN Yuan-Ming^1*, LIN Feng^2*, ZHANG Ming-Ming¹, WANG Zhao-Bin¹, ZHANG Min-Yi¹

1. Key Laboratory of Food Quality and Safety of Guangdong Province, Institute of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China;
2. Guangdong Inspection and Quarantine Technology Center Food Testing Laboratory, Guangzhou 510623, China

Received:2010-11-22 Revised:2011-03-18 Online:2011-10-10 Published:2011-09-11
Contact: SUN Yuan-Ming;LIN Feng E-mail:ymsun@scau.edu.cn;linf@iqtc.cn
Supported by:
国家“八六三”计划项目(批准号: 2007AA10Z437)、国家自然科学基金(批准号: 20877029, 30700663)和广东省科技厅关键领域重点突破招标项目(批准号: 2006A25005002)资助.

Abstract

Abstract: The metabonomics method was applied to investigate the effects of nonylphenol(NP) on urine metabolism in Sprague Dawley rat. The profiles of urine samples were obtained with high performance liquid chromatography coupled with time-of-flight mass spectrometry(HPLC/TOF-MS). The data were analyzed with the principle components analysis(PCA) to distinguish the differences of profiles between the NP groups and the control group. The potential biomarkers and effective biomarkers were screened out according to the t-test, and identified with Metlin Scripps Center for mass spectrometry database. The results indicated that the contents of phenyl glucuronide, homocystein, 3-nitropropionic acid, creatinine and 5-hydroxytryptamine changed obviously in urine after exposure to NP, which constituted the metabolic profiles in rat urine of NP, and might injury reproductive system, immune system, nervous system and lipometabolism in metabolism process. This study provides the basis for toxicology studies on NP to organisms from the standpoint of metabolism.

Key words: Nonylphenol, Metabonomics, HPLC/TOF-MS, Biomarker

CLC Number:

O657. 63

TrendMD:

WANG Wei-Hua, LIU Chun-Hong, SUN Yuan-Ming*, LIN Feng*, ZHANG Ming-Ming, WANG Zhao-Bin, ZHANG Min-Yi. Metabolic Profiles of Nonylphenol in Rat Urine[J]. Chem. J. Chinese Universities, 2011, 32(10): 2280.

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Metabolic Profiles of Nonylphenol in Rat Urine

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