Synthesis and Bioactivity of 2-Aceto-cyanoacetic Acid Derivatives

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (9): 1798.

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Synthesis and Bioactivity of 2-Aceto-cyanoacetic Acid Derivatives

LI Yang^1,2, ZHANG Zhi-Guo^2,3, CHI Hui-Wei², LUO Yan-Mei², LIU Chang-Ling², LI Zheng-Ming^1*

1. State Key Laboratory of Elemento-Organic Chemistry, National Pesticides Engineering Resarch Center, Nankai University, Tianjin 300071, China;
2. Shenyang Research Institute of Chemical Industry, Shenyang 110021, China;
3. College of Applied Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142, China

Received:2009-12-01 Online:2010-09-10 Published:2010-09-10
Contact: LI Zheng-Ming. E-mail: nkzml@vip.163.com
Supported by:
国家“十一五”科技支撑项目(批准号: 2006BAE01A01-2)资助.

Abstract

Abstract: For finding excellent acaricide, a series of novel 2-acyl-cyanoacetic acid derivatives was designed and synthesized based on cyflumetofen. Their structures were confirmed by ¹H NMR, IR and elemental analysis. Preliminary biological evaluation showed that several compounds had acaricidal activity, with compounds 4e and 4k having 100% control against Tetranychus cinnabarinus at 600 mg/L. Some compounds exhibited fungicidal activity and herbicidal activity, compounds 4k and 4s could completely control against Blumeria graminis at 400 mg/L, compound 4m had good control of Abutilon theophrasti at 1000 mg/L. The relationship between the structures and the biological activity was also discussed.

Key words: 2-Acyl-cyanoacetic acid derivative, Acaricidal activity, Fungicidal activity, Herbicidal activity

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LI Yang, ZHANG Zhi-Guo, CHI Hui-Wei, LUO Yan-Mei, LIU Chang-Ling, .... Synthesis and Bioactivity of 2-Aceto-cyanoacetic Acid Derivatives[J]. Chem. J. Chinese Universities, 2010, 31(9): 1798.

References

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Synthesis and Bioactivity of 2-Aceto-cyanoacetic Acid Derivatives

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