Abstract: In order to look for novel potential active pesticides, a series of ortho-dicarboxyamides developed from structures of chlorantraniliprole and fipronil, were designed and synthesized according to the bio-rational design principle. Their structures were characterized by ¹H NMR and HRMS. The preliminary results of biological experiments indicated that the title compounds exhibited unsatisfactory insecticidal activities against Mythimna separata Walker at 200 mg/L, however, at 50 mg/L, compounds 6e and 6f exhibited a fungicidal activity of 45.0% against Alternaria solani which is higher than the other compounds. The results indicated that the compounds contained 2,4,6-trichlorobenzene group showed the best fungicidal activities against Alternaria solani; compound 6g exhibited a fungicidal activity of 51.9% against Physalospora piricola which is better than the other compounds. The results indicated that the compounds contained the larger steric group showed the excellent fungicidal activities against Physalospora piricola.

Key words: Chlorantraniliprole, Fipronil, Dicarboxyamide, Insecticidal activity, Fungicidal activity