Carbon Nanotube-β-cyclodextrin Composites as Novel Matrix for Amino Acids and Small Molecular Polymer Analysis by MALDI-FT MS

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (9): 1729.

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Carbon Nanotube-β-cyclodextrin Composites as Novel Matrix for Amino Acids and Small Molecular Polymer Analysis by MALDI-FT MS

WEI Yuan-Long^1,2,4, ZHOU Wei³, LIU Fan^1,2, REN Zhi-Yu³, ZHANG Ling-Yi¹, DU Yi-Ping^1*, GUO Yin-Long^2*

1. School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;
2. Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
3. Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, Heilongjiang University, Harbin 150080, China;
4. Comprehensive Technology Center, Jiangxi Entry-exit Inspection and Quarantine Bureau, Nanchang 330002, China

Received:2010-01-27 Online:2010-09-10 Published:2010-09-10
Contact: DU Yi-Ping. E-mail: yipingdu@ecust.edu.cn; GUO Yin-Long. E-mail: ylguo@mail.sioc.ac.cn
Supported by:
国家“九七三”计划项目(批准号: 2007CB914104)\, 国家科技支撑计划(批准号: 2006BAK03A07)和国家自然科学基金(批准号: 20975039, 20675083, 20875097)资助.

Abstract

Abstract: Hydrophilic carbon nanotube-β-cyclodextrin(CNT-β-CD) composites were prepared as matrix by matrix assisted lasen desorption ionization-FT mass spectrum(MALDI-FT MS) for the analysis of amino acids and small molecular polymer. The composites were characterized by SEM, and the results showed that the products presented randomly oriented quasi-nanobeltlike structures. Moreover, compared with the traditional oxidized carbon nanotubes, the CNT-β-CD presented a lower background in matrix assisted lasen desorption ionization-mass spectrum(MALDI-MS). The composites were also evaluated by amino acids and polyethylene glycol(PEG), aiming at demonstrating the ability of desorption and ionization for samples. Intense signals corresponding to alkali cation adduct of amino acids and PEG were acquired, and they were independent of the background interference signals. Accordingly, CNT-β-CD is suitable for analysis of small molecules in MALDI-MS.

Key words: Matrix assisted lasen desorption ionization(MALDI), Carbon nanotube, β-Cyclodextrin(β-CD), Small molecule

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WEI Yuan-Long, ZHOU Wei, LIU Fan, REN Zhi-Yu, ZHANG Ling-Yi, DU Yi-Pi, .... Carbon Nanotube-β-cyclodextrin Composites as Novel Matrix for Amino Acids and Small Molecular Polymer Analysis by MALDI-FT MS[J]. Chem. J. Chinese Universities, 2010, 31(9): 1729.

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Carbon Nanotube-β-cyclodextrin Composites as Novel Matrix for Amino Acids and Small Molecular Polymer Analysis by MALDI-FT MS

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