Natural Anticoagulant and Endothelial Cell-Compatible Multilayer for Endovascular Stents Surface Modification

Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (6): 1256.

• Letters • Previous Articles

Natural Anticoagulant and Endothelial Cell-Compatible Multilayer for Endovascular Stents Surface Modification

LIN Quan-Kui, YAN Jia-Jie, JI Jian*, SHEN Jia-Cong

Department of Polymer Science and Engineering, Key Laboratory of Macromolecule Synthesis and Functionalization of Minster of Education, Zhejiang University, Hangzhou 310027, China

Received:2008-12-11 Online:2009-06-10 Published:2009-06-10
Contact: JI Jian, E-mail: jijian@zju.edu.cn
Supported by:
基金项目：国家“八六三”计划(批准号: 2006AA03Z329)、国家“九七三”计划(批准号: 2005CB623902)、浙江省科技计划(批准号: 2007C24008)和吉林大学超分子结构与材料国家重点实验室开放课题基金(批准号: SKLSSM200712)资助.

Abstract

Abstract:

Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation. In this research, a polyelectrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition. The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated multilayer took on excellent hemocompatibility. The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhesion and proliferation are greatly promoted after the multilayer modification. Such multilayered endovascular stents with excellent hemocompatibilty and human endothelial cytocompatibility may have great potential in clinical applications.

Key words: Layer-by-layer, Extracellular matrix, Anti-thrombosis, Cytocompatibility

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LIN Quan-Kui, YAN Jia-Jie, JI Jian*, SHEN Jia-Cong. Natural Anticoagulant and Endothelial Cell-Compatible Multilayer for Endovascular Stents Surface Modification[J]. Chem. J. Chinese Universities, 2009, 30(6): 1256.

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Natural Anticoagulant and Endothelial Cell-Compatible Multilayer for Endovascular Stents Surface Modification

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