Studies on the Acute Toxicity of Lu(NO3)3 by 1H NMR and Pattern Recognition Method

Abstract

Abstract: ¹HNMR spectroscopy and pattern recognition method were used to assess acute toxicological effects of rare earth. Male Wistar rats were treated with Lu(NO₃)_-3 at doses of 0.2, 2.0, 10 and 100 mg/kg body weight with NaCrO₄, HgCl₂, CCl₄, ANIT and N₂H₄₅HCl as the model toxins. The urine samples from the rats dosed with these compounds were collected over a 48 h time course and analyzed by 600 MHz ¹HNMR spectra. Each NMR spectrum was data-processed to provide 220 intensity-related descriptors of spectra. The urine spectral data were analyzed by SIMCA method and successful classification of the toxicity and biochemical effects of Lu(NO₃)₃ were achieved. The toxicity induced by lower doses(0.2 and 2 mg/kg body weight) of Lu(NO₃)₃ was classified to NaCrO₄ which produced lesion to proximal convoluted tubule cells, and the higher doses(10 and 100 mg/kg body weight) of Lu(NO₃)₃ could cause liver centrilobular necrosis like CCl₄.

Key words: Rare earth, Biofluid, NMR spectroscopy, Pattern recognition, Toxicity

CLC Number:

O657.2

TrendMD:

WU Hui-Feng, ZHANG Xiao-Yu, LI Xiao-Jing, SUN Guo-Ying, WU Yi-Jie, PEI Feng-Kui. Studies on the Acute Toxicity of Lu(NO₃)₃ by ¹H NMR and Pattern Recognition Method[J]. Chem. J. Chinese Universities, 2005, 26(7): 1321.

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Studies on the Acute Toxicity of Lu(NO₃)₃ by ¹H NMR and Pattern Recognition Method

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