Synthesis and Hill Inhibitory Activity of 2-Cyano-3-methylthiobenzyl Acrylates

Abstract

Abstract: Acrylates are important PSⅡ inhibitors, which always have high herbicidal activities. Based on target's structure, bio-rational molecular design and our previous studies, the title compounds were synthesized. All compounds were structurally confirmed by ¹H NMR, elemental analysis and IR. The Hill reaction inhibitory activity of them was tested and the results indicated that some showed the moderate inhibitory activity, in the result of that the benzene ring reduced the electron density of the β-oxygen atom in the ester chain, and hindered the better interaction between it and (Ser 268.) The relationship between the structure and activity was analyzed, which indicated the substituents on the benzene ring have influence on the activities.

Key words: PSⅡ inhibitors, Acrylates, Herbicidal activity, Structure-activity relationship

CLC Number:

O626

TrendMD:

GAO Ying, CHEN Xiao-Fang, LIU Bin, ZOU Xiao-Mao, HU Fang-Zhong, YANG Hua-Zheng. Synthesis and Hill Inhibitory Activity of 2-Cyano-3-methylthiobenzyl Acrylates[J]. Chem. J. Chinese Universities, 2005, 26(6): 1058.

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Synthesis and Hill Inhibitory Activity of 2-Cyano-3-methylthiobenzyl Acrylates

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