Self-assembly Behavior of Polypeptide Graft Copolymer

Abstract

Abstract: Polymeric micelles of poly(γ-benzyl L-glutamate)(PBLG)-poly(ethylene oxide)(PEO) graft copolymer were prepared by the dialysis method in deionized water. Fluorescence spectroscopy, nuclear magnetic resonance(NMR) and transmission electron microscope(TEM) were used for the investigation of the self-assembly of PBLG-PEO graft copolymer. Fluorescence spectrosco0y measurements suggest that PBLG-PEO graft copolymer associates to form polymeric micelles in water. ¹H NMR measurements further prove that in aqueous medium PBLG-PEO graft copolymer could assemble into polymeric micelles with PBLG segments as the hydrophobic inner core and PEO segments as the hydrophilic shell. The results of the TEM observations show that the polymeric micelles of PBLG-PEO graft copolymer are almost spindly shaped, which are different from the morphology of the spherical micelles formed by PBLG-PEO block copolymer. Polymeric micelles formed by polypeptide copolymer have potential application as drug carrier in controlled-release delivery system.

Key words: Polypeptide, Graft copolymer, Self-assembly, Micelle, Fluorescence

CLC Number:

O631

TrendMD:

CHEN Tao, TANG Dong-Mei, LIN Jia-Ping, ZHU Guo-Quan, ZHANG Sun-Ning, TIAN Xiao-Hui . Self-assembly Behavior of Polypeptide Graft Copolymer[J]. Chem. J. Chinese Universities, 2005, 26(5): 988.

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Self-assembly Behavior of Polypeptide Graft Copolymer

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