Studies on Interaction of Atorvastatin Calcium with β-Cyclodextrin and Its Application

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (11): 2023.

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Studies on Interaction of Atorvastatin Calcium with β-Cyclodextrin and Its Application

DONG She-Ying¹, HUANG Ting-Lin², ZHENG Jian-Bin³, GAO Hong³

1. College of Sciences;
2. School of Environment and Municipal Engineering Xi'an University of Architecture and Technology,Xi'an 710055,China;
3. Institute of Electroanalytical Chemistry,Northwest University,Xi'an 710069,China

Received:2004-12-17 Online:2005-11-10 Published:2005-11-10

Abstract

Abstract: The interaction of Atorvastatin calcium(AC) with β-cyclodextrin(β-CD) was studied by means of linear scan voltammetry,cyclic voltammetry and UV spectra.The experimental results show that electroactive molecule AC was complexed with β-CD to form 1:1 inclusion complex in 0.06 mol/L KH-2PO₄-Na-2HPO₄(pH=7.17) buffer solution.The inclusion constant was calculated to be 9.09×10⁴ L/mol by electric current method.In addition,an inclusion complex between β-CD and AC in NaOH solution was formed,which induced the decrease of adsorptive peak current of β-CD.Based on the characteristics,an indirect voltammetry for AC determination was found,and this method was more sensitive than the direct method.

Key words: Atorvastatin calcium(AC), β-Cyclodextrin(β-CD), Interaction, Inclusion complex

CLC Number:

O657.14

TrendMD:

DONG She-Ying, HUANG Ting-Lin, ZHENG Jian-Bin, GAO Hong. Studies on Interaction of Atorvastatin Calcium with β-Cyclodextrin and Its Application[J]. Chem. J. Chinese Universities, 2005, 26(11): 2023.

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Studies on Interaction of Atorvastatin Calcium with β-Cyclodextrin and Its Application

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