Synthesis and Characterization of Acrylic Ester Bridged γ-Substituted β-Diketone Pyrazole and Isoxazole Derivatives

Abstract

Abstract: Synthesis and characterization of a series of long-chain conjugated pyrazoles and isoxazoles were(achieved) through reaction the of acrylic ester bridged γ-substituted β-diketone with hydrazine hydrate and(hydroxylamine) hydrocholoride respectively.The influence of different solvents on the reactions was studied and the results reveal that the reaction outcome depends on the solvent.When alcohol was used as the solvent,isoxazoles were obtained via reaction of γ-substituted β-diketone and hydroxylamine hydrocholoride,while no target pyrazole compounds but α,β-saturated hydrazines were formed via reaction of γ-substituted β-diketone and hydrazine hydrate.When using acetic acid as the solvent,the target pyrazole compounds were obtained.The reaction mechanisms for the formation of α,β-saturated hydrazines were discussed.

Key words: (β-Diketone), Pyrazole, Isoxazoles, Liquid crystal, Hydrazine hydrate, Hydroxylamine hydro-(choloride)

CLC Number:

O626

TrendMD:

GUO Hui, HAN Jie, PANG Mei-Li, MA Yu-Xin, MENG Ji-Ben . Synthesis and Characterization of Acrylic Ester Bridged γ-Substituted β-Diketone Pyrazole and Isoxazole Derivatives[J]. Chem. J. Chinese Universities, 2005, 26(10): 1845.

References

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