Hemperfusion Adsorbents Used in the Removing of Endotoxin

Abstract

Abstract: A series of modified poly(methyl methacrylate) adsorbents were prepared and their adsorption abilities to endotoxin,which is a component of the outer membrance of Gram-negative bacteria,were compared. The results showed that the adsorbent modified by dimethylamine ligand with a long spacer had the best capacity for adsorbing endotoxin. The adsorbent P-N4,having a hydroxyl group at β -site of the ligand,could form the hydrogen bond with phosphate group. The electrostatic interaction,hydrogen bond and cooperative effect of octatomic ring worked simultaneously. All these factors are responsible for the strong interactions between endotoxin molecule and the adsorbent.

Key words: Endotoxin, Adsorption, Hemoperfusion.

CLC Number:

Q592.1
Q592.2

TrendMD:

YU Mei, WANG Hui-Yan, LIU Tao, YUAN Zhi . Hemperfusion Adsorbents Used in the Removing of Endotoxin[J]. Chem. J. Chinese Universities, 2004, 25(8): 1465.

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Hemperfusion Adsorbents Used in the Removing of Endotoxin

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