Preparation of Uniform-sized Molecularly Imprinted PolymerMicrospheres Using N-Cbz-L-Trp as Template

Abstract

Abstract: Uniform-sized molecularly imprinted polymer microspheres were prepared by using N-benzyloxycarbonyl-L-tryptophane(N-Cbz-L-Trp) as the template via a multi-step swelling and suspension polymerization method in which 2-vinylpyridine(2-VP) was used as the functional monomer and diethylene glycol diacrylate(DEGDA) was used as the cross-linker. The surfaces of nonporous micropheres were rough. The average diameter of polymer micropheres was 6.3 μm, and its distribution coeffiene was 1.03. It was found that the baseline chiral separation of the template enantiomer was achieved on a shorter column. Moreover, the removing of the template molecule and the thermal stability of MIP micropheres were also discussed.

Key words: Molecularly imprinted polymer, Uniform-sized dispersion, Amino acid derivatives

CLC Number:

O631

TrendMD:

GUO Tian-Ying, ZHANG Li-Ying, HAO Guang-Jie, SONG Mou-Dao, ZHANG Bang-Hua. Preparation of Uniform-sized Molecularly Imprinted PolymerMicrospheres Using N-Cbz-L-Trp as Template[J]. Chem. J. Chinese Universities, 2004, 25(4): 762.

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Preparation of Uniform-sized Molecularly Imprinted PolymerMicrospheres Using N-Cbz-L-Trp as Template

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