Abstract: To investigate the effects of SPEO surface architecture onto protein adsorption, a “loop-like” SPEO(surface A) and a “tail-like” SPEO(surface B), which had almost the same surface composition, were constructed Via a special thermal treatment. The contact angle on the Surface A/water interface decreased rapidly with increasing of the water hydration time. After longer water incubation, it presented a hydrophilic interface and impart significant resistant to both albumin and fibrinogen adsorption. But it is non selective for the albumin. By contrast, the contact angle on the Surface B/water interface decreased little with water hydration. It presented a hydrophobic interface, which exhibits a very low fibrinogen adsorption while adsorbing a high level of albumin. The results proved that surface B may keep a “tail-like” SPEO in aqueous solution and it is possible to get a glycocalyx mimic surface, in which a hydrophobic matrix was covered by a layer of flexible hydrophilic PEO and then by hydrophobic signal molecules. The theoretical analysis of the SPEO surface architecture onto protein adsorption was also explored preliminarily.

Key words: Amphiphilic graft copolymer, Biomimetic, Surface properties, Protein adsorption