An Optical Biosensor Based on Surface Plasmon Resonance for Determination of Human Cardiac Troponin I

Abstract

Abstract: A novel optical biosensor based on simultaneous multi-wavelength detection surface plasmon resonance(SPR) was developed for diagnosing acute myocardial infaction. The sensor was designed on the basis of fixing the angle of incidence and measuring the reflected intensities in the wavelength range of 400-800 nm. The SPR spectra are shown in terms of reflected light intensity verus wavelength of incident light. The intensity of the reflected light is the minimum at the resonant wavelength. On the sensing element of a right angle the glass prism is a thin(50 nm) metallic gold film coated by vacuum-deposition. Molecular self-assembling in solution is used to form the sensing membrane on the gold substrate. Human cardiac troponin I was determined in the concentration range of 5.0-50 μg/L. Under the selected experimental conditions, the sensor has a good sensitivity, repeatability, reversibility and selectivity.

Key words: Surface plasmon resonance, Sensor, Human cardiac troponin I

CLC Number:

O657.15

TrendMD:

SONG Da-Qian, LIU Xia, ZHAO Li-Wei, ZHANG Han-Qi, WEI Jing-Yan, MU Ying, LUO Gui-Min . An Optical Biosensor Based on Surface Plasmon Resonance for Determination of Human Cardiac Troponin I[J]. Chem. J. Chinese Universities, 2003, 24(7): 1185.

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An Optical Biosensor Based on Surface Plasmon Resonance for Determination of Human Cardiac Troponin I

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