Synthesis, Crystal Structure and Antibacterial Activity of Copper(Ⅱ) Complexes with 2-oxo-Propionic Acid Salicyloyl Hydrazone

Abstract

Abstract: Two copper(Ⅱ) complexes with 2-oxo-propionic acid salicyloyl hydrazone, Cu(C₁₀ H₈N₂O₄)·(H₂O)₂ (1) and Cu(C₁₀ H₈N₂O₄)(CH₃OH)(H₂O) (2) (C₁₀ H₈N₂O₄^2- is the dinegative ion of 2-oxo-propionic acid salicyloyl hydrazone), have been synthesized. Bottle green prismatic crystals of complex 2 were obtained, and the crystal structure was determined by single crystal X-ray diffraction. Complex 2 crystallized in the triclinic space group P1 with a=0.7538(2) nm, b=1.1431(2) nm, c=0.7500(2) nm, a=93.26(2)^o, β-=94.46(2)^o, γ =94.39(2)^o, V=0.6411(2) nm³, μ =1.731 mm^-1, Z=2, D_c=1.792 g/cm³, F(000)=342.00, GOF=1.78, R=0.035, wR=0.048 for 2630 observed reflections [ I>3.00σ(I)] out of 2946 unique reflections. In complex 2, Cu atom is square pyramidally coordinated by two Oatoms and one Natom of tridentate C₁₀ H₈N₂O₄^2- ligand, one Oatom of methanol molecule and one Oatom of water molecule with the Oatom of methanol molecule locating at the apical position. The crystal of complex 2 is a racemic compound, included a couple of enantiomers. The couples of enantiomers occur in the crystal of complex 2 in dimer bonding with two hydrogen bonds. According to elemental analyse and IR, the structure of complex 1 is supposed to be similar to that of complex 2. The results of biological activity tests show that complex 1 has 100% and 66.02% of bacteriostastic activity for phytophthora capsic and alternaria alternaea, respectively.

Key words: Copper(Ⅱ) complex, 2-Oxo-propionic acid salicyloyl hydrazone, Crystal structure, Autibacterialc activity

CLC Number:

O614

TrendMD:

HE Shui-Yang, CAO Wen-Kai, CHEN Jun-Li, ZHAO Jian-She, SHI Qi-Zhen . Synthesis, Crystal Structure and Antibacterial Activity of Copper(Ⅱ) Complexes with 2-oxo-Propionic Acid Salicyloyl Hydrazone[J]. Chem. J. Chinese Universities, 2002, 23(6): 991.

References

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