Temperature-constrained Cascade Correlation Network andIts Application to Bacteria Identification

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (4): 570.

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Temperature-constrained Cascade Correlation Network andIts Application to Bacteria Identification

ZHANG Zhuo-Yong¹, Aaron Urbas², Peter de B Harrington², Kent J. Voorhees³, Jon Rees³

1. Department of Chemistry, Capital Normal University, Beijing 100037, China;
2. Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701-2979, USA;
3. Department of Geochemistry, Colorado School of Mines, Golden, CO 80401, USA

Received:2001-01-05 Online:2002-04-24 Published:2002-04-24

Abstract

Abstract: The theoretical basis of temperature constrained cascade correlation network(TCCCN) was in-troduced briefly.The TCCCNmodels were used to identify various bacteria from their matrix-assistedlaser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data.The identificationof eight different bacteria and the bacteria identification based on different culture time have been dis-cussed.The results show that the TCCCNcould produce robust and feature-oriented models for bacteria i-dentification based on MALDI-TOF-MS.However, mis-identification may occur for some bacteria sam-ples due to variation in cell biology under environmental conditions.

Key words: Bacteria, MALDI, Time-of-flight mass spectrometry, TCCCN, Artificial neural network

CLC Number:

TrendMD:

ZHANG Zhuo-Yong, Aaron Urbas, Peter de B Harrington, Kent J. Voorhees, Jon Rees. Temperature-constrained Cascade Correlation Network andIts Application to Bacteria Identification[J]. Chem. J. Chinese Universities, 2002, 23(4): 570.

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Temperature-constrained Cascade Correlation Network andIts Application to Bacteria Identification

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