Studies on the Binding Nature in Molecularly Imprinted Polymer Selective for 4-Aminopyridine

Abstract

Abstract: Amolecularly imprinted polymer was prepared using 4-aminopyridine as template. The bulk polymer obtained was ground up, sieved and investigated in equilibrium binding experiments to evaluate the binding characteristics of the 4-aminopyridine imprinted polymer. Scatchard analysis showed that two classes of binding sites were produced in the polymer matrix and their dissociation constants were calculated to be 6.0 μmol/Land 1.2 mmol/Lrespectively, by utilizing the model of multiple independent classes of binding sites. The substrate selectivity of the polymer was investigated. The results showed that the imprinted polymer exhibited much higher affinity for 4-aminopyridine among the tested compounds. ₁HNMR studies and the analysis of the resonance structure of 4-aminopyridine indicated that the selective binding interaction between the template and binding sites in the polymer arose from their ionic interaction.

Key words: Molecular imprinting, 4 Aminopyridine, Molecular recognition, Substrates selectivity

CLC Number:

O657.32

TrendMD:

GUO Hong-Sheng, HE Xi-Wen, JING Ying, LIANG Hong . Studies on the Binding Nature in Molecularly Imprinted Polymer Selective for 4-Aminopyridine[J]. Chem. J. Chinese Universities, 2001, 22(5): 739.

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Studies on the Binding Nature in Molecularly Imprinted Polymer Selective for 4-Aminopyridine

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