Studies on the Reaction Between N-Phosphoryl Amino Acids and Ribonucleosides

Abstract

Abstract: The interaction between N-phosphoryl amino acids and nucleosides in aqueous medium was studied and the products were analyzed on the basis of HPLC and LC-MS-MS techniques. The results demonstrated that peptides and oligonucleotides were simultaneously formed. Different selectivities were observed between the reaction of various kinds of N-phosphoryl amino acids and different nucleosides. The results gave some clue for the chemical characteristics of the origin of primordial genetic code.

Key words: N-Phosphoryl amino acids, Nucleotide, Peptide, Origin of life, Primordial genetic code

CLC Number:

O621

TrendMD:

HU Jian-Jun, JU Yong, ZHAO Yu-Fen . Studies on the Reaction Between N-Phosphoryl Amino Acids and Ribonucleosides[J]. Chem. J. Chinese Universities, 2000, 21(11): 1667.

[1]	CAO Shujie, LI Hongjun, GUAN Wenli, REN Mengtian, ZHOU Chuanzheng. Progress on the Stereocontrolled Synthesis of Phosphorothioate Oligonucleotides [J]. Chem. J. Chinese Universities, 2022, 43(Album-4): 20220304.
[2]	WANG Baichun, YUAN Yuxin, YAN Yinghua, DING Chuanfan, TANG Keqi. Glucose-6-phosphate Functionalized Hydrophilic Magnetic Probe： a Dual-purpose Affinity Material for Effective Separation and Enrichment of Glycopeptides/Phosphopeptides [J]. Chem. J. Chinese Universities, 2021, 42(10): 3062.
[3]	HOU Chunxi, LI Yijia, WANG Tingting, LIU Shengda, YAN Tengfei, LIU Junqiu. Application of Elastin-like Polypeptides in Supramolecular Assembly ^† [J]. Chem. J. Chinese Universities, 2020, 41(6): 1163.
[4]	A Li, WANG Yong. Fluorescent Peptide Sensor for Detection of Copper Ions [J]. Chem. J. Chinese Universities, 2020, 41(12): 2736.
[5]	WANG Mengyu, CAO Simin, LI Haoyang, ZHANG Mengjie, LI Dong, ZHAO Zenan, XU Jianhua. Fluorescence Resonance Energy Transfer Between Coenzyme NADH and Tryptophan [J]. Chem. J. Chinese Universities, 2020, 41(11): 2473.
[6]	WEN Jing, XU Zhimin, QI Desheng, WANG Jiayu, YU Shuangjiang, HE Chaoliang, HAN Bing. PLG-g-TA/RGD Enzyme-catalyzed Crosslinked Hydrogel for Adhesion and Three-dimensional Culture of Hyaline Chondrocytes ^† [J]. Chem. J. Chinese Universities, 2019, 40(9): 2020.
[7]	LIU Bingtong, ZHUANG Yongliang. Structural Characterization of Peptide Calcium Chelate VGLPNSR-Ca and Its Calcium Absorption Ability in Caco-2 Cell Monolayer [J]. Chem. J. Chinese Universities, 2019, 40(8): 1643.
[8]	LIU Guomin, LU Tiancheng, JI Xuan, JIA Wenyuan, LI Yalong, ZHAO Yian, LUO Yungang. Preparation and Osteogenic Induction Activity of CBD-BMP2-MP/PLGA 3D Printed Composite Scaffolds^† [J]. Chem. J. Chinese Universities, 2019, 40(7): 1552.
[9]	CHANG Junpeng,ZHAO Jiarui,CHEN Sijia,MENG Kai,SHI Weini,LI Ruifang. Structure-activity Relationship of Antimicrobial Peptide SAMP1 and Its Analog Peptides^† [J]. Chem. J. Chinese Universities, 2019, 40(4): 705.
[10]	ZHANG Ye,WU Weihui,ZONG Liang,DONG Junjun. Carbonate Handle Modified Wang Resin and Its Function^† [J]. Chem. J. Chinese Universities, 2019, 40(3): 462.
[11]	QIAO Junqin,LIANG Chao,CAO Zhaoming,LIAN Hongzhen. Retention Behavior of Oligonucleotides under System Containing Mixed Ion-pair Reagents by IP-RPLC^† [J]. Chem. J. Chinese Universities, 2018, 39(9): 1893.
[12]	WU Fangling,CHU Yanqiu,CHEN Xin,WEI Wanghui,DING Chuanfan. Critical Factors Affecting Noncovalent Interaction Between Pentapeptides Explored by Electrospray Ionization Mass Spectrometry^† [J]. Chem. J. Chinese Universities, 2018, 39(9): 1927.
[13]	LU Tong, WANG Chunyang, ZHU Zhihui, JIANG Wei, HUO Mingnan, LI Fei. Polyethyleneimine Functionalized Graphene Oxide Against hIAPP Amyloid Aggregation^† [J]. Chem. J. Chinese Universities, 2018, 39(6): 1274.
[14]	GAO Jing,HUANG Keke,ZHANG Xianlong,SUN Yu,FENG Shouhua. Robust Self-assembly Properties of Glyceryl Decanoates Synthesized Under Wetting and Drying Cycles^† [J]. Chem. J. Chinese Universities, 2018, 39(5): 849.
[15]	CAO Hongyu,JIN Xiaojun,GUO Wei,YU Yaxian,SHI Longfei,TANG Qian,ZHENG Xuefang. Investigation on Binding Interactions Between Extracellular Amino-terminal Domain of GLP-1 Receptor Mutations and GLP-1 by Molecular Dynamics Simulations^† [J]. Chem. J. Chinese Universities, 2018, 39(5): 1026.

Studies on the Reaction Between N-Phosphoryl Amino Acids and Ribonucleosides

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments