In Vitro Antitumor Activity of Titanocene Glycine Complex and Its Interaction with DNA

Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (11): 1682.

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In Vitro Antitumor Activity of Titanocene Glycine Complex and Its Interaction with DNA

ZHANG Zhi-Gang, YANG Pin

Institute of Molecular Science, Shanxi University, Taiyuan 030006, China

Received:1999-04-27 Online:1999-11-24 Published:1999-11-24

Abstract

Abstract: Titanocene glycine complex, Cp²Ti(O₂CCH₂NH₃⁺Cl^-)₂, was found to have in vitro antitumor activity against Ethrlich ascites tumor cells. The interaction between Cp²Ti(O₂CCH₂NH₃⁺Cl^-)₂and DNA was investigated by agarose gel electrophoresis. The results suggested that no intercalation bonding exists between the compound and DNA, and the compound does not induce nicking of DNA.

Key words: Titanocene glycine complex, Antitumor, DNA, Agarose gel electrophoresis

CLC Number:

O614.4

TrendMD:

ZHANG Zhi-Gang, YANG Pin . In Vitro Antitumor Activity of Titanocene Glycine Complex and Its Interaction with DNA[J]. Chem. J. Chinese Universities, 1999, 20(11): 1682.

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In Vitro Antitumor Activity of Titanocene Glycine Complex and Its Interaction with DNA

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