Studies on the Reaction Between Ketorolac, Feprazone and Serum Albumin

Abstract

Abstract: In this paper, by applying fluorescence quenching method and energy transfer technique, the interaction of serum albumin(BSA and HSA) with ketorolac and feprazone was investigated. The binding sites and binding constants were obtained. According to the thermodynamic parameters, the main sorts of binding force can be known. The results show that two drugs and protein have strong interactions. The mechanism of quenching belongs to static quenching and the main sort of binding force is static-electricity gravitation.

Key words: Ketorolac, Feprazone, BSA, HSA, Fluorescence quenching method

CLC Number:

O657

TrendMD:

HE Ji-Xiang, JIANG Chong-Qiu, WANG Hong-Jian, WANG Jing-Zheng . Studies on the Reaction Between Ketorolac, Feprazone and Serum Albumin[J]. Chem. J. Chinese Universities, 1999, 20(10): 1548.

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Studies on the Reaction Between Ketorolac, Feprazone and Serum Albumin

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