Synthesis of Amphiphilic Phosphate Carbonate-Copolymers and Drug Release Property of Their Microspheres

Abstract

Abstract: Four amphiphilic phosphate carbonate copolymers were synthesized by polycondensation of bisphenol A, phosgene and 2-bromoethyl phosphorodichloridate, and then quaternized with trimethylamine. The copolymers obtained were characterized by IR, ¹HNMR and elemental analysis. Average molecular weight(M_n) and water contact angle were measured. The in vitro degradation of copolymers was studied in pH7.4 phosphate buffer solution at 37 ℃. Microspheres of these coploymer were prepared, their morphology, size and in vitro drug release of 5-Fu were also investigated.

Key words: Amphiphilic phosphate-carbonate copolymer, Microsphere, In vitro degradation

CLC Number:

O631

TrendMD:

KE Tian-Yi, ZHUO Ren-Xi. Synthesis of Amphiphilic Phosphate Carbonate-Copolymers and Drug Release Property of Their Microspheres[J]. Chem. J. Chinese Universities, 1998, 19(8): 1335.

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Synthesis of Amphiphilic Phosphate Carbonate-Copolymers and Drug Release Property of Their Microspheres

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