Synthesis of 3-Acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole and Studies on Their Cyclization

Abstract

Abstract: Fourteen new 2-acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazoles were prepared by nucleophilic displacement of acylhydrazine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole . Fourteen new 3-substituted-6-(2,4-dichloro-phenyl)-S-triazolo-1,3,4-oxadiazoles were obtained by treating 2-acylhydrazino-5-(2,4-dichloro phenyl)-1,3,4-oxadiazoles with K₂CO₃ solution. The structures of new compounds were determined by elementary and spectral analyses. All the new compounds showed a significant antibacterial activity.

Key words: 2,5-Disubstituted-1,3,4-oxadiazole, 3,6-Disubstituted-S-triazolo[3,4-b], 1,3,4-oxadiazole, Cyclization

CLC Number:

O626.26
O626.24

TrendMD:

FENG Xiao-Ming, HE Xun, JIANG Yao-Zhong . Synthesis of 3-Acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole and Studies on Their Cyclization[J]. Chem. J. Chinese Universities, 1998, 19(4): 577.

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Synthesis of 3-Acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole and Studies on Their Cyclization

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