Preparation of Chiral Stationary Phases Coated Using Cellulose Derivatives and Study of Chiral Resolution in HPLC

Abstract

Abstract: Optical resolution of a range of racemic compounds was investigated using cellulose tribenzate and trisphenylcarbamate coated onto a small-partial spherical organosilane modified silica. The influence on chiral discrimination of factors such as coated loadings and mobile phase was performed. The loadings of 15% on the support gave the best results. The regioselectivity of an asymmetric hydroesterification of styrene was determined by HPLCusing a chiral stationary phase(CTPC-CSP). Asatisfactory result had been obtained on CTPCchiral column with n-hexane/2-propanol(98/2 in volume ratio) as mobile phase.

Key words: HPLC, Cellulose derivatives, Chiral stationary phase, Optical resolution, Asymmetric hydroesterification

CLC Number:

O658

TrendMD:

HOU Jing-Guo, ZHOU Hong-Ying, JIANG Sheng-Xiang, ZHOU Zhi-Qiang, CHEN Li-Ren, OU Qing-Yu . Preparation of Chiral Stationary Phases Coated Using Cellulose Derivatives and Study of Chiral Resolution in HPLC[J]. Chem. J. Chinese Universities, 1998, 19(4): 538.

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Preparation of Chiral Stationary Phases Coated Using Cellulose Derivatives and Study of Chiral Resolution in HPLC

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