Studies on the Tyrosine-Based Polyphosphate Antitumor Drugs

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (1): 149.

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Studies on the Tyrosine-Based Polyphosphate Antitumor Drugs

FAN Chang-Lie, HU Bin, ZHUO Ren-Xi, DU Yang

Department of Chemistry, Wuhan University, Wuhan, 430072

Received:1996-01-23 Online:1997-01-24 Published:1997-01-24

Abstract

Abstract: New polyphosphate antitumor durgs containing 5-Fu or MTXwere synthesized by macromolecular reaction of polyphosphates with the corresponding drug molecules.All these polyphosphates obtained are amphiphilic, some of them have micelle-forming properties.The hydrolysis and in vitro drug release properties of these polyphosphates were studied.The in vitro antitumor activity data showed that some of these polyphosphates exhibit good antitumor activity.

Key words: Polyphosphate, Tyrosine, Amphiphilicity, 5-Fluorouracil, Methotrexate

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FAN Chang-Lie, HU Bin, ZHUO Ren-Xi, DU Yang . Studies on the Tyrosine-Based Polyphosphate Antitumor Drugs[J]. Chem. J. Chinese Universities, 1997, 18(1): 149.

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Studies on the Tyrosine-Based Polyphosphate Antitumor Drugs

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