Synthesis and Antiinflammatory Activity of 2-Alkyl Cyclopentenone Derivatives

Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (2): 258.

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Synthesis and Antiinflammatory Activity of 2-Alkyl Cyclopentenone Derivatives

QI Chuan-Min¹, JI Zhi-Zhong², LI Yu-Lan², WANG Biao²

1. Department of Applied Chemistry, Beijing Agricultural University, Beijing 100094;
2. Shenyang Pharmacceutical University

Received:1995-02-09 Online:1996-02-24 Published:1996-02-24

Abstract

Abstract: This paper reports the preparation of twelve novel 2-alkyl-5-arylidene cyclopentenones and their derivatives,The structures of all compounds have been confirmed by elementary analysis,IR,¹H NMRanalysis.Preliminary pharmacological test showed tl1at Ⅲ₁,Ⅲ₅,Ⅳ₂ and Ⅳ₃ given orally have a significant inhibiting effect on edema of mice ear induced by xylene.Further pharmacological examinations are in progress.

Key words: Cyclopentenone derivatives, β-Amiomethyl ketone, Mannich reaction, Condensation, Antiinflammation

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QI Chuan-Min, JI Zhi-Zhong, LI Yu-Lan, WANG Biao. Synthesis and Antiinflammatory Activity of 2-Alkyl Cyclopentenone Derivatives[J]. Chem. J. Chinese Universities, 1996, 17(2): 258.

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Synthesis and Antiinflammatory Activity of 2-Alkyl Cyclopentenone Derivatives

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