Studies on Structure-Activity Relationship of Epibatidine and Its Analogues

Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (12): 1893.

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Studies on Structure-Activity Relationship of Epibatidine and Its Analogues

XU Jian-Ping¹, HE Dong¹, WANG Zhi-Zhong², SHEN Jia-Cong¹, GAO Lian-Xun³, SONG Ya-Ru⁴

1. Department of Chemistry, Jilin University, Changchun, 130023;
2. Institute Theoretical Chemistry, Jilin University, Changchun, 130023;
3. Changchun Institute of Applied Chemistry;
4. Department of Chemistry, Beijing Normal University

Received:1995-11-29 Online:1996-12-24 Published:1996-12-24

Abstract

Abstract: This paper reported the investigation of structure-activity relationship of the strong analgetic alkaloid epibatidine and it's analogues by using AMImethod. Some information was given according to the calculation results of HOMO electron density and electron charge distribution etc.It is also indicated that the biophores were the bridge nitrogen and exo-pyridine moiety of these alkaloids.

Key words: Epibatidine, AMl, Alkaloid, Structure-activity relationship

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XU Jian-Ping, HE Dong, WANG Zhi-Zhong, SHEN Jia-Cong, GAO Lian-Xun, SONG Ya-Ru. Studies on Structure-Activity Relationship of Epibatidine and Its Analogues[J]. Chem. J. Chinese Universities, 1996, 17(12): 1893.

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Studies on Structure-Activity Relationship of Epibatidine and Its Analogues

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